Standard pelvic chemoradiotherapy prior to surgery can be safely omitted in select patients with locally advanced rectal cancer whose tumours respond to neoadjuvant chemotherapy, findings from a large cooperative group trial demonstrated.

A short course of perioperative chemotherapy for locally advanced esophageal/gastroesophageal junction (GEJ) cancer led to outcomes similar to those achieved with more intensive multimodal therapy, according to a randomised trial reported here.

“This is the most exciting time of my professional career,” says Professor David Thomas, “and I’ve been in medicine for 30 years.” By Ken Eastwood, NSW Health & Medical Research

Endocrine therapy (ET) alone was noninferior to ET plus chemotherapy for women with estrogen receptor (ER)−positive, HER2-negative, axillary node−negative, early-stage breast cancer (BC). ASCO Annual Meeting – Tim Donald, ELS